Acyclic nucleoside phosphonates containing the amide bond
Identifieur interne : 000887 ( Main/Exploration ); précédent : 000886; suivant : 000888Acyclic nucleoside phosphonates containing the amide bond
Auteurs : Iwona E. Głowacka [Pologne] ; Dorota G. Piotrowska [Pologne] ; Graciela Andrei [Belgique] ; Dominique Schols [Belgique] ; Robert Snoeck [Belgique] ; Andrzej E. Wr Blewski [Pologne]Source :
- Monatshefte Fur Chemie [ 0026-9247 ] ; 2016.
Abstract
To study the influence of a linker rigidity and donor–acceptor properties, the P–CH2–
Url:
DOI: 10.1007/s00706-016-1848-x
PubMed: 27881885
PubMed Central: 5101293
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000148
- to stream Pmc, to step Curation: 000148
- to stream Pmc, to step Checkpoint: 000297
- to stream Ncbi, to step Merge: 000590
- to stream Ncbi, to step Curation: 000590
- to stream Ncbi, to step Checkpoint: 000590
- to stream Main, to step Merge: 000889
- to stream Main, to step Curation: 000887
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Acyclic nucleoside phosphonates containing the amide bond</title><author><name sortKey="Glowacka, Iwona E" sort="Glowacka, Iwona E" uniqKey="Glowacka I" first="Iwona E." last="Głowacka">Iwona E. Głowacka</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz</wicri:regionArea><wicri:noRegion>90-151 Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Piotrowska, Dorota G" sort="Piotrowska, Dorota G" uniqKey="Piotrowska D" first="Dorota G." last="Piotrowska">Dorota G. Piotrowska</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz</wicri:regionArea><wicri:noRegion>90-151 Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Andrei, Graciela" sort="Andrei, Graciela" uniqKey="Andrei G" first="Graciela" last="Andrei">Graciela Andrei</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Schols, Dominique" sort="Schols, Dominique" uniqKey="Schols D" first="Dominique" last="Schols">Dominique Schols</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Snoeck, Robert" sort="Snoeck, Robert" uniqKey="Snoeck R" first="Robert" last="Snoeck">Robert Snoeck</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Wr Blewski, Andrzej E" sort="Wr Blewski, Andrzej E" uniqKey="Wr Blewski A" first="Andrzej E." last="Wr Blewski">Andrzej E. Wr Blewski</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz</wicri:regionArea><wicri:noRegion>90-151 Lodz</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27881885</idno><idno type="pmc">5101293</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101293</idno><idno type="RBID">PMC:5101293</idno><idno type="doi">10.1007/s00706-016-1848-x</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000148</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000148</idno><idno type="wicri:Area/Pmc/Curation">000148</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000148</idno><idno type="wicri:Area/Pmc/Checkpoint">000297</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000297</idno><idno type="wicri:Area/Ncbi/Merge">000590</idno><idno type="wicri:Area/Ncbi/Curation">000590</idno><idno type="wicri:Area/Ncbi/Checkpoint">000590</idno><idno type="wicri:doubleKey">0026-9247:2016:Glowacka I:acyclic:nucleoside:phosphonates</idno><idno type="wicri:Area/Main/Merge">000889</idno><idno type="wicri:Area/Main/Curation">000887</idno><idno type="wicri:Area/Main/Exploration">000887</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Acyclic nucleoside phosphonates containing the amide bond</title><author><name sortKey="Glowacka, Iwona E" sort="Glowacka, Iwona E" uniqKey="Glowacka I" first="Iwona E." last="Głowacka">Iwona E. Głowacka</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz</wicri:regionArea><wicri:noRegion>90-151 Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Piotrowska, Dorota G" sort="Piotrowska, Dorota G" uniqKey="Piotrowska D" first="Dorota G." last="Piotrowska">Dorota G. Piotrowska</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz</wicri:regionArea><wicri:noRegion>90-151 Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Andrei, Graciela" sort="Andrei, Graciela" uniqKey="Andrei G" first="Graciela" last="Andrei">Graciela Andrei</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Schols, Dominique" sort="Schols, Dominique" uniqKey="Schols D" first="Dominique" last="Schols">Dominique Schols</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Snoeck, Robert" sort="Snoeck, Robert" uniqKey="Snoeck R" first="Robert" last="Snoeck">Robert Snoeck</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Louvain</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Wr Blewski, Andrzej E" sort="Wr Blewski, Andrzej E" uniqKey="Wr Blewski A" first="Andrzej E." last="Wr Blewski">Andrzej E. Wr Blewski</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz</wicri:regionArea><wicri:noRegion>90-151 Lodz</wicri:noRegion></affiliation></author></analytic><series><title level="j">Monatshefte Fur Chemie</title><idno type="ISSN">0026-9247</idno><idno type="eISSN">1434-4475</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Abstract</title><p>To study the influence of a linker rigidity and donor–acceptor properties, the P–CH<sub>2</sub>–<bold>O–CHR</bold>– fragment in acyclic nucleoside phosphonates (e.g., acyclovir, tenofovir) was replaced by the P–CH<sub>2</sub>–<bold>HN–C(O)</bold>– residue. The respective phosphonates were synthesized in good yields by coupling the straight chain of <italic>ω</italic>-aminophosphonates and nucleobase-derived acetic acids with EDC. Based on the <sup>1</sup>H and <sup>13</sup>C NMR data, the unrestricted rotation within the methylene and 1,2-ethylidene linkers in phosphonates from series <bold>a</bold> and <bold>b</bold> was confirmed. For phosphonates containing 1,3-propylidene (series <bold>c</bold>) fragments, antiperiplanar disposition of the bulky <italic>O</italic>,<italic>O</italic>-diethylphosphonate and substituted amidomethyl groups was established. The synthesized ANPs P–X–HNC(O)–CH<sub>2</sub>B (X = CH<sub>2</sub>, CH<sub>2</sub>CH<sub>2</sub>, CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>, CH<sub>2</sub>OCH<sub>2</sub>CH<sub>2</sub>) appeared inactive in antiviral assays against a wide variety of DNA and RNA viruses at concentrations up to 100 μM while marginal antiproliferative activity (L1210 cells, IC<sub>50</sub> = 89 ± 16 μM and HeLa cells, IC<sub>50</sub> = 194 ± 19 μM) was noticed for the analog derived from (5-fluorouracyl-1-yl)acetic acid and <italic>O</italic>,<italic>O</italic>-diethyl (2-aminoethoxy)methylphosphonate.</p></sec><sec><title>Graphical abstract</title><p><graphic position="anchor" xlink:href="706_2016_1848_Figa_HTML" id="MO1"></graphic></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author><author><name sortKey="Holy, A" uniqKey="Holy A">A Holy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Magee, Wc" uniqKey="Magee W">WC Magee</name></author><author><name sortKey="Evans, Dh" uniqKey="Evans D">DH Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holm, L" uniqKey="Holm L">L Holm</name></author><author><name sortKey="Bockermann, R" uniqKey="Bockermann R">R Bockermann</name></author><author><name sortKey="Wellner, E" uniqKey="Wellner E">E Wellner</name></author><author><name sortKey="Baecklund, J" uniqKey="Baecklund J">J Baecklund</name></author><author><name sortKey="Holmdahl, R" uniqKey="Holmdahl R">R Holmdahl</name></author><author><name sortKey="Kihlberg, J" uniqKey="Kihlberg J">J Kihlberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blomberg, D" uniqKey="Blomberg D">D Blomberg</name></author><author><name sortKey="Kreye, P" uniqKey="Kreye P">P Kreye</name></author><author><name sortKey="Fowler, Cs" uniqKey="Fowler C">CS Fowler</name></author><author><name sortKey="Brickmann, K" uniqKey="Brickmann K">K Brickmann</name></author><author><name sortKey="Kihlberg, J" uniqKey="Kihlberg J">J Kihlberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hedenstrom, M" uniqKey="Hedenstrom M">M Hedenström</name></author><author><name sortKey="Yuan, Zq" uniqKey="Yuan Z">ZQ Yuan</name></author><author><name sortKey="Brickmann, K" uniqKey="Brickmann K">K Brickmann</name></author><author><name sortKey="Carlsson, J" uniqKey="Carlsson J">J Carlsson</name></author><author><name sortKey="Ekholm, K" uniqKey="Ekholm K">K Ekholm</name></author><author><name sortKey="Johansson, B" uniqKey="Johansson B">B Johansson</name></author><author><name sortKey="Kreutz, E" uniqKey="Kreutz E">E Kreutz</name></author><author><name sortKey="Nilsson, A" uniqKey="Nilsson A">A Nilsson</name></author><author><name sortKey="Sethson, I" uniqKey="Sethson I">I Sethson</name></author><author><name sortKey="Kihlberg, J" uniqKey="Kihlberg J">J Kihlberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peyman, A" uniqKey="Peyman A">A Peyman</name></author><author><name sortKey="Uhlmann, E" uniqKey="Uhlmann E">E Uhlmann</name></author><author><name sortKey="Wagner, K" uniqKey="Wagner K">K Wagner</name></author><author><name sortKey="Augustin, S" uniqKey="Augustin S">S Augustin</name></author><author><name sortKey="Breipohl, G" uniqKey="Breipohl G">G Breipohl</name></author><author><name sortKey="Will, Dw" uniqKey="Will D">DW Will</name></author><author><name sortKey="Schaefer, A" uniqKey="Schaefer A">A Schaefer</name></author><author><name sortKey="Wallmeier, H" uniqKey="Wallmeier H">H Wallmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kehler, J" uniqKey="Kehler J">J Kehler</name></author><author><name sortKey="Henriksen, U" uniqKey="Henriksen U">U Henriksen</name></author><author><name sortKey="Vejbjerg, H" uniqKey="Vejbjerg H">H Vejbjerg</name></author><author><name sortKey="Dahl, O" uniqKey="Dahl O">O Dahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Laan, Ac" uniqKey="Van Der Laan A">AC van der Laan</name></author><author><name sortKey="Havenaar, P" uniqKey="Havenaar P">P Havenaar</name></author><author><name sortKey="Oosting, Rs" uniqKey="Oosting R">RS Oosting</name></author><author><name sortKey="Kuyl Yeheskiely, E" uniqKey="Kuyl Yeheskiely E">E Kuyl-Yeheskiely</name></author><author><name sortKey="Uhlmann, E" uniqKey="Uhlmann E">E Uhlmann</name></author><author><name sortKey="Van Boom, Jh" uniqKey="Van Boom J">JH van Boom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Efimov, Va" uniqKey="Efimov V">VA Efimov</name></author><author><name sortKey="Buryakova, Aa" uniqKey="Buryakova A">AA Buryakova</name></author><author><name sortKey="Choob, Mv" uniqKey="Choob M">MV Choob</name></author><author><name sortKey="Chakhmakhcheva, G" uniqKey="Chakhmakhcheva G">G Chakhmakhcheva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalman, Fk" uniqKey="Kalman F">FK Kalman</name></author><author><name sortKey="Woods, M" uniqKey="Woods M">M Woods</name></author><author><name sortKey="Caravan, P" uniqKey="Caravan P">P Caravan</name></author><author><name sortKey="Jurek, P" uniqKey="Jurek P">P Jurek</name></author><author><name sortKey="Spiller, M" uniqKey="Spiller M">M Spiller</name></author><author><name sortKey="Tircso, G" uniqKey="Tircso G">G Tircso</name></author><author><name sortKey="Kiraly, R" uniqKey="Kiraly R">R Kiraly</name></author><author><name sortKey="Bruecher, E" uniqKey="Bruecher E">E Bruecher</name></author><author><name sortKey="Sherry, Ad" uniqKey="Sherry A">AD Sherry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gali, H" uniqKey="Gali H">H Gali</name></author><author><name sortKey="Prabhu, Kr" uniqKey="Prabhu K">KR Prabhu</name></author><author><name sortKey="Karra, Sr" uniqKey="Karra S">SR Karra</name></author><author><name sortKey="Katti, Kv" uniqKey="Katti K">KV Katti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koszytkowska Stawinska, M" uniqKey="Koszytkowska Stawinska M">M Koszytkowska-Stawinska</name></author><author><name sortKey="De Clercq, E" uniqKey="De Clercq E">E De Clercq</name></author><author><name sortKey="Balzarini, J" uniqKey="Balzarini J">J Balzarini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wheeler, Hl" uniqKey="Wheeler H">HL Wheeler</name></author><author><name sortKey="Liddle, Lm" uniqKey="Liddle L">LM Liddle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tada, M" uniqKey="Tada M">M Tada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrer, E" uniqKey="Ferrer E">E Ferrer</name></author><author><name sortKey="Shevchenko, A" uniqKey="Shevchenko A">A Shevchenko</name></author><author><name sortKey="Eritja, R" uniqKey="Eritja R">R Eritja</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rabinowitz, Jl" uniqKey="Rabinowitz J">JL Rabinowitz</name></author><author><name sortKey="Gurin, S" uniqKey="Gurin S">S Gurin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, P" uniqKey="Li P">P Li</name></author><author><name sortKey="Zhan, C" uniqKey="Zhan C">C Zhan</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Ding, X" uniqKey="Ding X">X Ding</name></author><author><name sortKey="Guo, F" uniqKey="Guo F">F Guo</name></author><author><name sortKey="He, S" uniqKey="He S">S He</name></author><author><name sortKey="Yao, J" uniqKey="Yao J">J Yao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katritzky, Ar" uniqKey="Katritzky A">AR Katritzky</name></author><author><name sortKey="Narindoshvili, T" uniqKey="Narindoshvili T">T Narindoshvili</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wojciechowski, F" uniqKey="Wojciechowski F">F Wojciechowski</name></author><author><name sortKey="Hudson, Rhe" uniqKey="Hudson R">RHE Hudson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwergold, C" uniqKey="Schwergold C">C Schwergold</name></author><author><name sortKey="Depecker, G" uniqKey="Depecker G">G Depecker</name></author><author><name sortKey="Di Giorgio, C" uniqKey="Di Giorgio C">C Di Giorgio</name></author><author><name sortKey="Patino, N" uniqKey="Patino N">N Patino</name></author><author><name sortKey="Jossinet, F" uniqKey="Jossinet F">F Jossinet</name></author><author><name sortKey="Ehresmann, B" uniqKey="Ehresmann B">B Ehresmann</name></author><author><name sortKey="Terreux, R" uniqKey="Terreux R">R Terreux</name></author><author><name sortKey="Cabrol Bass, D" uniqKey="Cabrol Bass D">D Cabrol-Bass</name></author><author><name sortKey="Condom, R" uniqKey="Condom R">R Condom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joullie, Mm" uniqKey="Joullie M">MM Joullié</name></author><author><name sortKey="Lassen, Km" uniqKey="Lassen K">KM Lassen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Faham, A" uniqKey="El Faham A">A El-Faham</name></author><author><name sortKey="Albericio, F" uniqKey="Albericio F">F Albericio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunetz, Jr" uniqKey="Dunetz J">JR Dunetz</name></author><author><name sortKey="Magano, J" uniqKey="Magano J">J Magano</name></author><author><name sortKey="Weisenburger, Ga" uniqKey="Weisenburger G">GA Weisenburger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falkiewicz, B" uniqKey="Falkiewicz B">B Falkiewicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noel, O" uniqKey="Noel O">O Noel</name></author><author><name sortKey="Xie, J" uniqKey="Xie J">J Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Cola, C" uniqKey="De Cola C">C De Cola</name></author><author><name sortKey="Manicardi, A" uniqKey="Manicardi A">A Manicardi</name></author><author><name sortKey="Corradini, R" uniqKey="Corradini R">R Corradini</name></author><author><name sortKey="Izzo, I" uniqKey="Izzo I">I Izzo</name></author><author><name sortKey="De Riccardis, F" uniqKey="De Riccardis F">F De Riccardis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macmillan, Ds" uniqKey="Macmillan D">DS MacMillan</name></author><author><name sortKey="Murray, J" uniqKey="Murray J">J Murray</name></author><author><name sortKey="Sneddon, Hf" uniqKey="Sneddon H">HF Sneddon</name></author><author><name sortKey="Craig, J" uniqKey="Craig J">J Craig</name></author><author><name sortKey="Watson, Ajb" uniqKey="Watson A">AJB Watson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Basavaprabhu" uniqKey="Basavaprabhu">Basavaprabhu</name></author><author><name sortKey="Vishwanatha, Tm" uniqKey="Vishwanatha T">TM Vishwanatha</name></author><author><name sortKey="Panguluri, Nr" uniqKey="Panguluri N">NR Panguluri</name></author><author><name sortKey="Sureshbabu, Vv" uniqKey="Sureshbabu V">VV Sureshbabu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheehan, Jc" uniqKey="Sheehan J">JC Sheehan</name></author><author><name sortKey="Preston, J" uniqKey="Preston J">J Preston</name></author><author><name sortKey="Cruickshank, Pa" uniqKey="Cruickshank P">PA Cruickshank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nozaki, S" uniqKey="Nozaki S">S Nozaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doboszewski, B" uniqKey="Doboszewski B">B Doboszewski</name></author><author><name sortKey="Groaz, E" uniqKey="Groaz E">E Groaz</name></author><author><name sortKey="Herdewijn, P" uniqKey="Herdewijn P">P Herdewijn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hockova, D" uniqKey="Hockova D">D Hockova</name></author><author><name sortKey="Keough, Dt" uniqKey="Keough D">DT Keough</name></author><author><name sortKey="Janeba, Z" uniqKey="Janeba Z">Z Janeba</name></author><author><name sortKey="Wang, Th" uniqKey="Wang T">TH Wang</name></author><author><name sortKey="De Jersey, J" uniqKey="De Jersey J">J de Jersey</name></author><author><name sortKey="Guddat, Lw" uniqKey="Guddat L">LW Guddat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, X" uniqKey="Pan X">X Pan</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name></author><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z Hu</name></author><author><name sortKey="Shan, Y" uniqKey="Shan Y">Y Shan</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pischel, H" uniqKey="Pischel H">H Pischel</name></author><author><name sortKey="Holy, A" uniqKey="Holy A">A Holy</name></author><author><name sortKey="Vesely, J" uniqKey="Vesely J">J Vesely</name></author><author><name sortKey="Wagner, G" uniqKey="Wagner G">G Wagner</name></author><author><name sortKey="Cech, D" uniqKey="Cech D">D Cech</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiemer, Aj" uniqKey="Wiemer A">AJ Wiemer</name></author><author><name sortKey="Wiemer, Df" uniqKey="Wiemer D">DF Wiemer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>Pologne</li></country><region><li>Province du Brabant flamand</li></region><settlement><li>Louvain</li></settlement></list><tree><country name="Pologne"><noRegion><name sortKey="Glowacka, Iwona E" sort="Glowacka, Iwona E" uniqKey="Glowacka I" first="Iwona E." last="Głowacka">Iwona E. Głowacka</name></noRegion><name sortKey="Piotrowska, Dorota G" sort="Piotrowska, Dorota G" uniqKey="Piotrowska D" first="Dorota G." last="Piotrowska">Dorota G. Piotrowska</name><name sortKey="Wr Blewski, Andrzej E" sort="Wr Blewski, Andrzej E" uniqKey="Wr Blewski A" first="Andrzej E." last="Wr Blewski">Andrzej E. Wr Blewski</name></country><country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="Andrei, Graciela" sort="Andrei, Graciela" uniqKey="Andrei G" first="Graciela" last="Andrei">Graciela Andrei</name></region><name sortKey="Schols, Dominique" sort="Schols, Dominique" uniqKey="Schols D" first="Dominique" last="Schols">Dominique Schols</name><name sortKey="Snoeck, Robert" sort="Snoeck, Robert" uniqKey="Snoeck R" first="Robert" last="Snoeck">Robert Snoeck</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000887 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000887 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5101293
|texte= Acyclic nucleoside phosphonates containing the amide bond
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27881885" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |